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Scientist III, Cancer Immunology & Immune Modulation

Description:   We are seeking a highly motivated Scientist III with strong interpersonal communication skills to join the growing, innovative Cancer Immunology & Immune Modulation (CI & IM) Research Group at Boehringer Ingelheim's US research facility in Ridgefield, CT. The successful candidate will work within the CI&IM in vivo pharmacology group to advance both exploratory and drug candidate discovery programs and provide target discovery/validation, in-vivo efficacy, mechanism of action (MOA) and pharmacodynamic data essential to drive projects into clinical development. The ideal candidate will collaborate with other members of in-vivo teams and with key responsibilities involving primarily designing and conducting in vivo pharmacology models of inflammation and oncology, as well as establishing early PK/PD for lead progression.   As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.   Responsibilities: Execute research projects according to the experimental design, ensure technically capable and provide accurate, reliable and reproducible data. Independently perform in vivo studies, proficient in data collection/documentation, interpret data and with mentorship, present to project teams. Collaborate extensively with other members of the Immune Modulation Group in Ridgefield, while synergizing effectively with the in vivo pharmacology group in the Inflammation & Respiratory therapeutic area. Expand scientific/technical knowledge and skill sets by regularly reading relevant scientific literature and implement learnings in the study designs or project strategies. Ensure that the highest standard of animal welfare is maintained in all studies involving experimental animals. Understand and implement study protocol according to AAALAC and IACUC guidelines. Qualifications: Master's Degree from an accredited institution with three-plus (3+) years of experience in related scientific discipline, OR Bachelor's Degree from an accredited institution with seven-plus (7+) years of experience in related scientific discipline or equivalent experience in related field Extensive hands-on experience on conducting rodent experiments including preparation of test compounds, handling and dosing mice by various routes (IP, SC, IV or PO), collection of blood and tissues for PK and PD biomarker analysis. Familiar with human or murine primary cell isolation, cytokine profiling by ELISA or MSD, T cell and/or myeloid cell functional assays, Western blot, and qPCR.  Experience in using multi-color flow cytometry (FACS) to evaluate immune cell biomarkers and data analysis software is a plus. Past experience with syngeneic or xenograft tumor models or PDX models is preferred. Familiarity with hydrodynamic tail vein injection is a plus but not required. Excellent oral and written communication skills. Proficiency in all common Microsoft Office and Graphpad Prism software. Strong ability to multi-task and willingness to work effectively in a fast-paced, highly collaborative, and diverse research environment. The ability to both work independent and be a team player. Eligibility Requirements: Must be legally authorized to work in the United States without restriction. Must be willing to take a drug test and post-offer physical (if required) Must be 18 years of age or older 1813149
Salary Range: NA
Minimum Qualification
8 - 10 years

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