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Senior Scientist or Principal Scientist - DMPK

Description: The DMPK Department is looking to further enhance its scientific talent base at our R&D site in Ridgefield, CT. We're looking for scientists at multiple levels who will propose and implement in vitro and in vivo experiments in support of our development candidates. Additional responsibilities include supporting multiple projects; defining, implementing, and communicating tactics for achieving overall R&D project goals; and carefully evaluating and interpreting data. Description\: Employer is seeking a highly motivated Senior Scientist or Principal Scientist to join the Drug Metabolism & Pharmacokinetics (DMPK) department at our US headquarters in Ridgefield, CT. As a Senior Scientist or Principal Scientist, you will be responsible for conducting in vitro studies to evaluate the interaction of drugs, metabolites, and reference compounds with drug metabolizing enzymes. You will be expected to evaluate and interpret the data generated, apply the knowledge gained from these studies toward the advancement of compounds in our Development portfolio, and contribute to scientific advancement in the field of drug metabolism and pharmacokinetics. Active and productive collaboration with other DMPK scientists, both internally and externally, is also required. You will be expected to propose and implement new techniques, effectively manage and prioritize multiple projects, and implement strategies to reach predetermined milestones and achieve R&D and corporate goals. As an employee of Employer, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Employer's high regard for our employees. Duties & Responsibilities\: Design, conduct, interpret, and report data from in vitro metabolism studies using various cellular and subcellular systems, e.g. microsomes, hepatocytes, and transfected cells. Integrate data from transporter studies with drug metabolism and pharmacokinetic concepts, including but not limited to PBPK modeling. Conduct routine LC-MS/MS based analysis of samples; also maintain, troubleshoot, and solve assay development problems Communicate results and interpretation of data through oral presentations and written documents to other DMPK colleagues, multidisciplinary project teams, and management. Comply with applicable regulations, demonstrate the ability to perform all work in a safe manner, and maintain proper records in accordance with SOPs and policies. Requirements\: Ph.D. degree (0-5 years of experience) in Drug Metabolism, Pharmacokinetics, Chemistry, Biochemistry, or other relevant discipline. Experience with the design and conduct of experiments to evaluate the interaction of molecules with drug metabolizing enzymes. An in depth knowledge of drug metabolizing enzymes and an advanced understanding of pharmacokinetic principles would be considered highly beneficial. Experience with studies involving drug transporters would be advantageous. Post-doctoral experience (up to 2 years) would be advantageous. Experience with the safe and appropriate use of radioactivity for in vitro studies is preferred. Effective oral and written communication skills are essential. Desired Skills, Experience and Abilities\: Previous supervisory experience preferred for Principal Scientist level Eligibility Requirements\: Must be legally authorized to work in the United States without restriction. Must be willing to take a drug test and post-offer physical (if required) Must be 18 years of age or older Our Culture\: Employer is a different kind of pharmaceutical company, a privately held company with the ability to have an innovative and long term view. Our focus is on scientific discoveries that improve patients' lives and we equate success as a pharmaceutical company with the steady introduction of truly innovative medicines. Employer is the largest privately held pharmaceutical corporation in the world and ranks among the world's 20 leading pharmaceutical corporations. At Employer, we are committed to delivering value through innovation. Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture and drive allows us to maintain one of the highest levels of excellence in our industry. Employer, including Employer Pharmaceuticals, Inc., Employer USA, Employer Animal Health USA, Inc., Merial Barceloneta, LLC and Employer Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce - Minority/Female/Protected Veteran/Person with a Disability. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. Employer is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers. As part of that commitment, Employer conducts pre-employment verifications and drug screenings. #LI-SS1 Department: Research & Development

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