Senior Scientist/Scientist IV, PK/PD - Quantitative Systems

Description: Description\: Design and implement mechanistic PK/PD and quantitative systems pharmacology models in support of Employer's innovative pre-clinical New Biological Entity (NBE) R&D portfolio. Represent the PK/PD modeling discipline on multi-disciplinary teams and integrate PK/PD considerations into team strategy. Collaborate with key stakeholders in pre-clinical and clinical development in support of the overall translational research strategy for projects. Enhance capabilities of group by implementing novel modeling approaches and technologies. As an employee of Employer, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Employer's high regard for our employees. Duties & Responsibilities\: Independently develops pre-clinical PK/PD and quantitative systems pharmacology models that enhance decision making for NBE target and candidate selections and inform translational research strategies for NBEs Uses modeling and simulation to predict human efficacious dose/dose regimen, and influences selection of first-in-human starting dose Designs, analyzes and interprets quantitative pharmacology and pharmacokinetic data and communicates results to teams and management Leverages literature data or proposes new experiments to validate models or test model-generated hypotheses Develops new methodologies, protocols or procedures that contribute to core group/research goals and reflect expert knowledge PK/PD modeling representative on multiple cross-functional project teams Effectively collaborates with scientists within and outside functional area (e.g. therapeutic area biologists and molecule discovery scientists Prepares clear technical reports, publications and oral presentations Develops broad knowledge in field of expertise and enhances internal capabilities of group Presents work at internal/external scientific meetings and publishes work in scientific journals Prepares clear technical reports, publications and oral presentations; Independently communicates results in the form of reports and or presentations; Presents responsibly and defends own work at meetings; May deliver updates to senior level management in context of overall project goals Develops expertise in a specific project-relevant area or technology; May provide guidance and expertise to advance specific projects or evaluates and proposes new technologies and concepts in support of multiple projects; Ability to work with various LIMS; Compilation of associated outputs with supervision Keeps abreast of relevant literature; Assumes responsibility for direct reports as needed including recruiting, managing, mentoring and developing scientific staff Complies with all applicable regulations; Ensures that work performed in area of responsibility is conducted in a safe and compliant manner; Maintains proper records in accordance with SOPs and policies Contributes to departmental administration; Demonstrates fiscal responsibility with respect to cost of experiments, technology, external collaborations, and travel Senior Scientist Requirements\: Ph.D. Degree Pharmacokinetics, Pharmaceutical sciences, Pharmacology or related discipline with proven track record of applying modeling and simulation approaches in academia or industry or equivalent experience in a related field Theoretical and practical knowledge of pharmacokinetics, PK/PD and quantitative systems pharmacology modeling Experience using one or more commercially available modeling and simulation platforms (e.g. Phoenix/WinNonlin, ADAPT, NONMEM, MATLAB, SimBiology, etc.) Experience in mechanism-based PK/PD modeling of therapeutic proteins is highly desired Ability to build effective working relationships and influence others both inside and outside department Strong aptitude for sharing expertise with cross-functional and global teams Ability to communicate effectively both orally and in writing in an interdisciplinary environment Committed to professional development of self and others Scientist IV Requirements\: Master's Degree in Pharmacokinetics, Pharmaceutical sciences, Pharmacology with 6+ years' experience in a related scientific discipline or Bachelor's Degree in Pharmacokinetics, Pharmaceutical sciences, Pharmacology with 10+ years' experience in related scientific discipline. Requires excellent communication, interpersonal & organizational skills; Requires ability to operate independently. Supplemental technical courses in area of expertise Ability to operate laboratory equipment with independence Ability to draft technical reports Demonstrate written and verbal communication skills Concise and accurate reporting of technical data and interpretation thereof Proven problem solving ability Able to act for supervisor in his/her absence Appropriate level of understanding of applicable regulations Eligibility Requirements\: Must be legally authorized to work in the United States without restriction. Must be willing to take a drug test and post-offer physical (if required) Must be 18 years of age or older Our Culture\: Employer is one of the world's top 20 pharmaceutical companies and operates globally with approximately 50,000 employees. Since our founding in 1885, the company has remained family-owned and today we are committed to creating value through innovation in three business areas including human pharmaceuticals, animal health and biopharmaceutical contract manufacturing. Since we are privately held, we have the ability to take an innovative, long-term view. Our focus is on scientific discoveries and the introduction of truly novel medicines that improve lives and provide valuable services and support to patients and their families. Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture and drive allows us to maintain one of the highest levels of excellence in our industry. We are also deeply committed to our communities and our employees create and engage in programs that strengthen the neighborhoods where we live and work. Employer, including Employer Pharmaceuticals, Inc., Employer USA, Employer Animal Health USA, Inc., Merial Barceloneta, LLC and Employer Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender identity or expression; affectional or sexual orientation; disability; veteran or military status, including protected veteran status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. Employer is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers. As part of that commitment, Employer conducts pre-employment verifications and drug screenings. #LI-SS1 Department: Research & Development

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